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KMID : 0829320080110020112
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Korean Journal of Clinical Microbiology
2008 Volume.11 No. 2 p.112 ~ p.116
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Evaluation of Rapid Assay (Toc A/B Quik Chek) for the Detection of Clostridium difficile Toxins A and B
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Kim Sue-Jung
Lee Kyung-Won
Chong Yun-Sop
Koh Eun-Mi
Kim Myung-Sook
Kim Hee-Jung
Kim Chang-Ki
Jeong Seok-Hoon
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Abstract
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Background: Toxin immunoassay is widely used for rapid diagnosis of Clostridium difficile-associated diarrhea. The aim of this study was to evaluate the performance of Tox A/B Quik Chek test (TECHLAB, Blacksburg, VA, USA) compared to toxigenic culture.
Methods: From September 2006 to August 2007, 959 stools were examined by Tox A/B Quik Chek test and toxigenic culture (C. difficile culture plus tcdB PCR using colonies obtained from culture).
Results: Compared to the results of toxigenic culture, the sensitivity and specificity of Tox A/B Quik Chek test were 47.5% and 97.5%, respectively.
Conclusion: The sensitivity of Tox A/B Quik Chek test was not high, but the specificity was high. Although Tox A/B Quik Chek test alone is not sufficient to diagnose Clostridium difficile-associated diarrhea, it may aid rapid diagnosis, early treatment and prevention of nosocomial spread of the infection, if supplemented by C. difficile culture or tissue culture cytotoxin assay. (Korean J Clin Microbiol 2008;11:112-116)
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KEYWORD
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Clostridium difficile, Enzyme immunoassay, Clostridium difficile Toxin A, Clostridium dif-ficile Toxin B
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